The prognosis of patients with hematopoietic stem cell transplants (HSCTs) who requireadmission to the intensive care unit (ICU) has been regarded as extremely poor. We sought tore-evaluate recent outcomes and predictive factors in a retrospective cohort study. Among the605 adult patients that received an HSCT between 2001 and 2006, 154 required admission to theICU. Of these, 47% were discharged from the ICU, 36% were discharged from the hospital, and19% survived 6 months. Allogeneic transplant, mechanical ventilation, vasopressor-use, andneutropenia were each associated with increased mortality, and the mortality of patients with allfour characteristics was 100%. Hemodialysis was also associated with increased mortality in aKaplan-Meier analysis but did not appear important in a multivariate tree analysis. A final Coxmodel confirmed that allogeneic transplant, mechanical ventilation, and vasopressor-use wereeach independent risk factors for mortality in the 6 months following ICU admission.
展开▼
